Neurexin

From Proteopedia

Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry 2xb6) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Structural highlights Function Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4[1]. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See: Neurodevelopmental Disorders Neuroligin-Neurexin Interaction Relevance NRXN sequence variants may contribute to autism spectrum disorder and other cognitive diseases[2]. Structural highlights The is mediated by a [3]. Water molecules are shown as red spheres.

3D Structures of Neurexin

07-November-2019

References

1. ↑ Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci. 2003 Jul;6(7):708-16. PMID:12796785 doi:http://dx.doi.org/10.1038/nn1074
2. ↑ Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan;82(1):199-207. doi: 10.1016/j.ajhg.2007.09.011. PMID:18179900 doi:http://dx.doi.org/10.1016/j.ajhg.2007.09.011
3. ↑ Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P. Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J. 2010 Jul 21;29(14):2461-71. Epub 2010 Jun 11. PMID:20543817 doi:10.1038/emboj.2010.123