From Proteopedia

Jump to: navigation, search

  Export Animated Image
Mouse neuroglobin showing the heme and complexed with sulfate and Xe 3gk9
Ligands: , ,
Gene: Ngb (Mus musculus)
Related: 3gkt, 3gln
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Neuroglobin (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly. It increases oxygen availability in the brain. It is a monomer containing a heme group[1].


NGB may influence the course of Alzhheimer's disease[2].

3D Structures of Neuroglobin

Updated on 09-May-2016

3gk9, 3gkt, 2vry, 1q1f, 4mu5, 4nzi, 4o1t, 4o4t – mNGB (mutant) – mouse
3gln, 1w92, 4o2g, 4o35 – mNGB (mutant) + CO
4o4z – mNGB (mutant) + N2O
1oj6 – hNGB (mutant) - human
4mpm – hNGB
4b4y – NGB – Symsagittifera roscoffensis


  1. Uzan J, Dewilde S, Burmester T, Hankeln T, Moens L, Hamdane D, Marden MC, Kiger L. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Biophys J. 2004 Aug;87(2):1196-204. PMID:15298922 doi:
  2. Sun F, Mao X, Xie L, Greenberg DA, Jin K. Neuroglobin protein is upregulated in Alzheimer's disease. J Alzheimers Dis. 2013;36(4):659-63. doi: 10.3233/JAD-130323. PMID:23648513 doi:

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Personal tools