P53-DNA Recognition

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This page, as it appeared on July 26, 2012, was featured in this article in the Journal of Biochemistry and Molecular Biology Education.

Human p53 core complex with DNA (PDB code 3kz8).

3D structures of p53

P53

Acknowledgements

This Proteopedia page originates from the partnership of the Rohs Laboratory at the University of Southern California with La Cañada High School. This partnership was initiated by Remo Rohs and Patty Compeau in September 2011 as Bioinformatics Institute, which is part of the Institutes of the 21st Century. Advice and technical help by Proteopedia editors Eran Hodis, Eric Martz, Jaime Prilusky, and Joel Sussman is acknowledged.

References

  1. 1.0 1.1 1.2 1.3 Kitayner M, Rozenberg H, Rohs R, Suad O, Rabinovich D, Honig B, Shakked Z. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs. Nat Struct Mol Biol. 2010;17(4):423-9. PMID:20364130.
  2. Jeffrey PD, Gorina S, Pavletich NP. Crystal structure of the p53 tetramerization domain. Science 1995;267:1498-502. PMID:7878469.
  3. Kitayner M, Rozenberg H, Kessler N, Rabinovich D, Shaulov L, Haran TE, Shakked Z. Structural basis of DNA recognition by p53 tetramers. Mol Cell. 2006 Jun 23;22(6):741-53. PMID:16793544.
  4. Horvath MM, Wang X, Resnick MA, Bell DA. Divergent evolution of human p53 binding sites: cell cycle versus apoptosis. PLoS Genet. 2007 Jul;3(7):e127. PMID:17677004.
  5. Rohs R, West SM, Sosinsky A, Liu P, Mann RS, Honig B. The role of DNA shape in protein-DNA recognition. Nature. 2009;461(7268):1248-53. PMID:19865164.
  6. Aishima J, Gitti RK, Noah JE, Gan HH, Schlick T, Wolberger C. A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic Acids Res. 2002;30(23):5244-52. PMID:12466549.
  7. Chen Y, Dey R, Chen L. Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure. 2010;18(2):246-56. PMID:20159469.
  8. Nikolova EN, Kim E, Wise AA, O'Brien PJ, Andricioaei I, Al-Hashimi HM. Transient Hoogsteen base pairs in canonical duplex DNA. Nature. 2011;470(7335):498-502. PMID:21270796.
  9. Rohs R, Jin X, West SM, Joshi R, Honig B, Mann RS. Origins of specificity in protein-DNA recognition. Annu Rev Biochem. 2010;79:233-69. PMID:20334529.

Proteopedia Page Contributors and Editors (what is this?)

Remo Rohs, Eric Martz, Alexander Berchansky, Julia Tam, Sharon Kim, Bailey Holmes, Angel Herraez, Joseph M. Steinberger, Eran Hodis, Masha Karelina, Michal Harel, Ana Carolina Dantas Machado, Jaime Prilusky, Skyler Saleebyan, Joel L. Sussman, Keziah Kim

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