Function
PDZ and LIM domain proteins (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure[1].
For details on PDLIM see Group:MUZIC:ZASP and Group:MUZIC:Enigma Family.
- PDLIM1 promotes cell attachment at the cytoskeleton. For details see Group:MUZIC:ALP.
- PDLIM2 may have a role in bringing proteins to the cytoskeleton.
- PDLIM3 may have a role in organizing actin filament arrays within muscle cells.
- PDLIM4 is a Zn+2 ion binding protein.
- PDLIM5 has important role in heart development by scaffolding PKC to the Z-disk region.
- PDLIM7 is an adaptor protein localizing the LIM-binding proteins to muscle tissues.
Relevance
PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.
