Palmitoyl protein thioesterase

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This page, as it appeared on May 3, 2014, was featured in this article in the journal Biochemistry and Molecular Biology Education.

Human Palmitoyl-protein thioesterase 1 (PPT-1) homodimer (PDB: 3gro)


References

  1. Wang R, Borazjani A, Matthews AT, Mangum LC, Edelmann MJ, Ross MK. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry. 2013 Oct 29;52(43):7559-74. doi: 10.1021/bi401138s. Epub 2013 Oct, 18. PMID:24083319 doi:http://dx.doi.org/10.1021/bi401138s
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Bellizzi JJ 3rd, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4573-8. PMID:10781062 doi:10.1073/pnas.080508097
  3. 3.0 3.1 Simonati A, Tessa A, Bernardina BD, Biancheri R, Veneselli E, Tozzi G, Bonsignore M, Grosso S, Piemonte F, Santorelli FM. Variant late infantile neuronal ceroid lipofuscinosis because of CLN1 mutations. Pediatr Neurol. 2009 Apr;40(4):271-6. doi: 10.1016/j.pediatrneurol.2008.10.018. PMID:19302939 doi:http://dx.doi.org/10.1016/j.pediatrneurol.2008.10.018
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Bellizzi JJ 3rd, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J. The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4573-8. PMID:10781062 doi:10.1073/pnas.080508097
  5. 5.0 5.1 5.2 Branneby, Cecilia. "Exploiting Enzyme Promiscuity for Rational Design." KTH Biotechnology (2005): Web. 10 Apr. 2013.
  6. 6.0 6.1 Hofmann SL, Das AK, Yi W, Lu JY, Wisniewski KE. Genotype-phenotype correlations in neuronal ceroid lipofuscinosis due to palmitoyl-protein thioesterase deficiency. Mol Genet Metab. 1999 Apr;66(4):234-9. PMID:10191107 doi:http://dx.doi.org/10.1006/mgme.1999.2803
  7. 7.0 7.1 Dawson G, Schroeder C, Dawson PE. Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease. Biochem Biophys Res Commun. 2010 Apr 23;395(1):66-9. doi:, 10.1016/j.bbrc.2010.03.137. Epub 2010 Mar 25. PMID:20346914 doi:http://dx.doi.org/10.1016/j.bbrc.2010.03.137
  8. Vines DJ, Warburton MJ. Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I. FEBS Lett. 1999 Jan 25;443(2):131-5. PMID:9989590
  9. Mitchison HM, Taschner PE, Kremmidiotis G, Callen DF, Doggett NA, Lerner TJ, Janes RB, Wallace BA, Munroe PB, O'Rawe AM, Gardiner RM, Mole SE. Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein. Neuropediatrics. 1997 Feb;28(1):12-4. PMID:9151311 doi:http://dx.doi.org/10.1055/s-2007-973656

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External Resources

Gauche Effect Wikipedia page

Palmitic acid Wikipedia page

Infantile Neuronal Ceroid Lipofuscinosis Wikipedia page

PMSF Wikipedia page

Protein Chaperones Wikipedia page

Endoplasmic reticulum Wikipedia page

Palmitoylation Wikipedia page

Page on Late Infantile neuronal Ceroid Lipofuscinosis

Page on Juvenile neuronal Ceroid Lipofuscinosis

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