Phosphoinositide phosphatase

From Proteopedia

Human 5PTase complex with phosphoinositol 4-phospate, glycerol, sulfate, Cl- (green) and Mg+2 (light green) ions (PDB code 3mtc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Phosphoinositide phosphatase degrades phosphoinositide signals[1]. PTEN is phosphatidylinositol 3,4,5-triphosphate 3-phosphatase and dual-specificity protein phosphatase. For details of PTEN phosphatase see PTEN PTEN function PTEN (Hebrew) Disease Mutations in the Sac phosphatase lead to degenerative neuropathy[2]. Structural highlights The . Alpha Helices,  Beta Strands ,  Loops , Turns. . Water molecules are shown as red spheres. . (PDB code 3mtc).[3]

3D Structures of phosphoinositide phosphatase

Updated on 04-August-2019

References

1. ↑ Dyson JM, Fedele CG, Davies EM, Becanovic J, Mitchell CA. Phosphoinositide phosphatases: just as important as the kinases. Subcell Biochem. 2012;58:215-79. doi: 10.1007/978-94-007-3012-0_7. PMID:22403078 doi:http://dx.doi.org/10.1007/978-94-007-3012-0_7
2. ↑ Liu Y, Bankaitis VA. Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res. 2010 Jul;49(3):201-17. doi: 10.1016/j.plipres.2009.12.001. Epub, 2010 Jan 5. PMID:20043944 doi:http://dx.doi.org/10.1016/j.plipres.2009.12.001
3. ↑ Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P. Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases. Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254 doi:http://dx.doi.org/10.1016/j.str.2014.01.013