Plexin

From Proteopedia

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Plexin (PLX) is the receptor for semaphorin[1]. Plexin A controls axon guidance[2]. Plexin B regulates Rho GTPase[3]. Plexin C is the receptor for GPI-anchored semaphorin Sema7A[4]. Structural highlights . Water molecules are shown as red spheres. . 3D structures of plexin Plexin 3D structures

References

1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200
4. ↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995