Proteopedia:Previously Featured Articles

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The Ribosome - Featured Oct. 18th, 2009 - Current Date

By Wayne Decatur

On October 7th, 2009 the Nobel Committee announced three structural biologists would share the 2009 Nobel Prize in Chemistry for studies of the The Ribosome. The ribosome is the machine in your cells that accurately and efficiently decodes the genetic information stored in your genome and synthesizes the corresponding polypeptide chain one amino acid at a time in the process of translation. Venkatraman Ramakrishnan of the M.R.C. Laboratory of Molecular Biology in Cambridge, England; Thomas A. Steitz of Yale University; and Ada E. Yonath of the Weizmann Institute of Science in Rehovot, Israel share the prize for the first atomic-resolution structures of the two subunits that come together to form an active ribosome. These structures are considered landmarks for the fact they showed clearly the major contributions to decoding and peptide bond synthesis come from RNA and not protein, as well as for the sheer size of the structures determined. These structures represent tour-de-force efforts in understanding fundamental processes in every organism on earth and will have direct impacts on how we fight pathogenic bacteria in the immediate future. Shown are both subunits of the ribosome, as well as that bind in the complex during the process of translation. Read more....

Poly(A) Polymerase - Featured Dec. 15, 2008 - May 2nd 2009

By Eran Hodis

Poly(A) polymerase binds specifically to ATP and adds it the end of a mRNA chain. This structure contains an oligo(A) polynucleotide with 5 nucleotides, an ATP molecule, and a magnesium ion. … In the , the enzyme is shown as a blue backbone, the RNA chain in yellow, the ATP in red, the Mg++ in green, and ALA154 in magenta. Several mechanisms are used to achieve the specificity for ATP. The Mg++ is coordinated by , and the Mg++ coordinates with the phosphates of ATP, positioning the nucleotide in the active site. The adenine base is sandwiched between the . Read more...

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David Canner, Eran Hodis, Jaime Prilusky

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