Pyrin domain

From Proteopedia

NMR structure of pyrin domain in human NLRP7, 2km6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal[1]. Disease Mutations in the protein are the cause of Familial Mediterranean fever[2].

3D Structures of Pyrin domain

Updated on 08-February-2022

4im6 – hPYD in NLRP1 – human
6x6a, 6x6c - hPYD in NLRP1 + DPP9
4ifp - hPYD in NLRP1/MBP
2naq - hPYD in NLRP3 - NMR
6npy - hPYD in NLRP3 + NEK7 - Cryo EM
4ewi - hPYD in NLRP4
6ncv - hPYD in NLRP6 - Cryo EM
6ndj - hPYD in NLRP6/MBP
2km6 – hPYD in NLRP7 – NMR
6z2g - hPYD in NLRP9
[[2m5v], 7bso] - hPYD in NLRP10
2l6a - hPYD in NLRP12 - NMR
4xhs - hPYD in NLRP12/MBP
4n1j, 4n1k, 4n1l - hPYD in NLRP14
4o7q - hPYD (mutant) in AIM2
3vd8 - hPYD in AIM2/MBP
2wl1 – hPYD PRYSPRY residues 586-776
1pn5 – hPYD in NALP1 - NMR
3qf2 - hPYD in NALP3
1ucp - hPYD in apoptosis-associated speck-like protein – NMR
2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR
2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR
2mpc - hPYD in pyrin - NMR
2do9 – mPYD in NALP10 – mouse – NMR
2yu0 – mPYD in interferon-activable protein 205 - NMR
7lfh - mPYD in NLRP3 - Cryo EM

References

1. ↑ Fairbrother WJ, Gordon NC, Humke EW, O'Rourke KM, Starovasnik MA, Yin JP, Dixit VM. The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci. 2001 Sep;10(9):1911-8. PMID:11514682 doi:http://dx.doi.org/10.1110/ps.13801
2. ↑ Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer HD, Grutter C, Grutter M, Tschopp J. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 2007 Aug;14(8):1457-66. Epub 2007 Apr 13. PMID:17431422 doi:http://dx.doi.org/10.1038/sj.cdd.4402142