Pyrrolysyl-tRNA synthetase

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Pyrrolysyl-tRNA synthetase complex with ATP analog and tert-butoxycarbo-lysine (PDB code 2zin)

3D structures of pyrrolysyl-tRNA synthetase

Updated on 28-December-2017

Additional Resources

For Additional information, see: Translation

References

  1. 1.0 1.1 Herring S, Ambrogelly A, Polycarpo CR, Soll D. Recognition of pyrrolysine tRNA by the Desulfitobacterium hafniense pyrrolysyl-tRNA synthetase. Nucleic Acids Res. 2007;35(4):1270-8. Epub 2007 Jan 31. PMID:17267409 doi:10.1093/nar/gkl1151
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 Yanagisawa T, Ishii R, Fukunaga R, Kobayashi T, Sakamoto K, Yokoyama S. Multistep engineering of pyrrolysyl-tRNA synthetase to genetically encode N(epsilon)-(o-azidobenzyloxycarbonyl) lysine for site-specific protein modification. Chem Biol. 2008 Nov 24;15(11):1187-97. PMID:19022179 doi:10.1016/j.chembiol.2008.10.004
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Urbancsek J, Rabe T, Grunwald K, Kiesel L, Papp Z, Runnebaum B. High preovulatory serum luteinizing hormone level is unfavorable to conception. Gynecol Endocrinol. 1991 Dec;5(4):223-33. PMID:1796745
  4. Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D. An aminoacyl-tRNA synthetase that specifically activates pyrrolysine. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12450-4. Epub 2004 Aug 16. PMID:15314242 doi:10.1073/pnas.0405362101
  5. 5.0 5.1 5.2 Nozawa K, O'Donoghue P, Gundllapalli S, Araiso Y, Ishitani R, Umehara T, Soll D, Nureki O. Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecular basis of orthogonality. Nature. 2009 Feb 26;457(7233):1163-7. Epub 2008 Dec 31. PMID:19118381 doi:10.1038/nature07611
  6. 6.0 6.1 Soares JA, Zhang L, Pitsch RL, Kleinholz NM, Jones RB, Wolff JJ, Amster J, Green-Church KB, Krzycki JA. The residue mass of L-pyrrolysine in three distinct methylamine methyltransferases. J Biol Chem. 2005 Nov 4;280(44):36962-9. Epub 2005 Aug 11. PMID:16096277 doi:10.1074/jbc.M506402200
  7. Polycarpo CR, Herring S, Berube A, Wood JL, Soll D, Ambrogelly A. Pyrrolysine analogues as substrates for pyrrolysyl-tRNA synthetase. FEBS Lett. 2006 Dec 11;580(28-29):6695-700. Epub 2006 Nov 20. PMID:17126325 doi:10.1016/j.febslet.2006.11.028
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Yanagisawa T, Ishii R, Fukunaga R, Kobayashi T, Sakamoto K, Yokoyama S. Crystallographic studies on multiple conformational states of active-site loops in pyrrolysyl-tRNA synthetase. J Mol Biol. 2008 May 2;378(3):634-52. Epub 2008 Feb 29. PMID:18387634 doi:10.1016/j.jmb.2008.02.045
  9. 9.0 9.1 9.2 9.3 Ibba M, Soll D. Genetic code: introducing pyrrolysine. Curr Biol. 2002 Jul 9;12(13):R464-6. PMID:12121639

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