RNA

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RNA (ribonucleic acid) is a biological macromolecule that stores and processes genetic information, catalyzes chemical reactions and regulates biological processes. Just like the other nucleic acid (DNA), it is a linear polymer (a "strand") of nucleotide building blocks. These building blocks themselves are made up of a sugar linked to a (nitrogenous) base and a phosphate. RNA utilizes a different set of bases than DNA, and it sugar (ribose) contains one additional hydroxyl group compared to that of DNA (deoxyribose). Different than DNA, which mostly occurs in pairs of complementary strands in its biological context, RNA mostly lacks a complementary strand, leading to a larger variety of 3D structures and biological functions.


RNA structure and function

Chemistry

  1. Base: flat, aromatic, hydrogen-bonding capability, base modifications, base pairing, base stacking
  2. Sugar phosphate backbone: torsion angles, sugar pucker, phosphate-phosphate distance

Transcription and Translation

The expression of genes into proteins and is a process involving two stages called transcription and translation. In the transcription stage a strand of DNA molecule serves as a template for the synthesis of an RNA molecule called messenger RNA. In the case of RNAs that code for polypetides, this messenger RNA is then translated into proteins on ribosomes.

Post-transcriptionally, specific nucleotides in RNA are often further modified. This is most frequent in [tRNA|transfer ribonucleic acid (tRNAs)]], the adapter molecules of Translation, and ribosomal ribonucleic acids (rRNAs) of the ribosome.

See Also

External Resources

References

  1. Steitz TA. The structural changes of T7 RNA polymerase from transcription initiation to elongation. Curr Opin Struct Biol. 2009 Dec;19(6):683-90. doi: 10.1016/j.sbi.2009.09.001., Epub 2009 Oct 5. PMID:19811903 doi:http://dx.doi.org/10.1016/j.sbi.2009.09.001
  2. Toor N, Rajashankar K, Keating KS, Pyle AM. Structural basis for exon recognition by a group II intron. Nat Struct Mol Biol. 2008 Nov;15(11):1221-2. Epub 2008 Oct 26. PMID:18953333 doi:10.1038/nsmb.1509

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