RNA Interference

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guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.

Schematic of RNAi Interference in Mammalian Cells
Schematic of RNAi Interference in Mammalian Cells

viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Articles in Proteopedia concerning RNA Interference include:


See RNAi in action by viewing this RNAi Animation.


To view automatically seeded indices concerning RNA Interference, see:


To view other Proteopedia pages about diseases & drug targets, see: Pharmaceutical Drug Targets

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Wayne Decatur, Eric Martz

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