Reverse transcriptase

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HIV-1 reverse transcriptase P66 subunit (grey) and P51 subunit (green) complex with sulfate 3dlk

3D Structures of Reverse transcriptase

Updated on 25-October-2017

See Also


References

  1. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science. 1992 Jun 26;256(5065):1783-90. PMID:1377403 doi:[http://dx.doi.org/10.1126/science.1377403 http://dx.doi.org/10.1126/science.1377403
  2. Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J Mol Biol. 2009 Jan 23;385(3):693-713. doi: 10.1016/j.jmb.2008.10.071. Epub 2008, Nov 3. PMID:19022262 doi:http://dx.doi.org/10.1016/j.jmb.2008.10.071
  3. ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function DOI: 10.1002/ijch.201200096
  4. Abbondanzieri EA, Bokinsky G, Rausch JW, Zhang JX, Le Grice SF, Zhuang X. Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature. 2008 May 8;453(7192):184-9. PMID:18464735 doi:10.1038/nature06941

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