SAGA-associated factor

From Proteopedia

Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow), UB8P (grey), glycerol and Zn+2 ions (grey) (PDB entry 3mhs) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes[1]. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation[2]. SGF73 is required for the assembly of RITS complex in yeast[3]. .

3D structures of SAGA-associated factor

Updated on 09-March-2022

References

1. ↑ Mischerikow N, Spedale G, Altelaar AF, Timmers HT, Pijnappel WW, Heck AJ. In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA. J Proteome Res. 2009 Nov;8(11):5020-30. doi: 10.1021/pr900449e. PMID:19731963 doi:http://dx.doi.org/10.1021/pr900449e
2. ↑ Schram AW, Baas R, Jansen PW, Riss A, Tora L, Vermeulen M, Timmers HT. A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation. PLoS One. 2013 Jul 23;8(7):e70035. doi: 10.1371/journal.pone.0070035. Print 2013. PMID:23894581 doi:http://dx.doi.org/10.1371/journal.pone.0070035
3. ↑ Deng X, Zhou H, Zhang G, Wang W, Mao L, Zhou X, Yu Y, Lu H. Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast. Sci Rep. 2015 Oct 7;5:14707. doi: 10.1038/srep14707. PMID:26443059 doi:http://dx.doi.org/10.1038/srep14707