SARS-CoV-2 enzyme RdRp

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Structure of replicating SARS-CoV-2 polymerase (PDB: 6YYT).

References

  1. Modeling of the SARS-COV-2 Genome
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  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Peng Q, Peng R, Yuan B, Zhao J, Wang M, Wang X, Wang Q, Sun Y, Fan Z, Qi J, Gao GF, Shi Y. Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2. Cell Rep. 2020 Jun 16;31(11):107774. doi: 10.1016/j.celrep.2020.107774. Epub 2020, May 30. PMID:32531208 doi:http://dx.doi.org/10.1016/j.celrep.2020.107774
  4. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 2020 Apr 10. pii: science.abb7498. doi: 10.1126/science.abb7498. PMID:32277040 doi:http://dx.doi.org/10.1126/science.abb7498
  5. Hillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P. Structure of replicating SARS-CoV-2 polymerase. Nature. 2020 May 21. pii: 10.1038/s41586-020-2368-8. doi:, 10.1038/s41586-020-2368-8. PMID:32438371 doi:http://dx.doi.org/10.1038/s41586-020-2368-8
  6. 6.0 6.1 Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait BT, Kapoor TM, Darst SA, Campbell EA. Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell. 2020 Jul 28. pii: S0092-8674(20)30941-7. doi: 10.1016/j.cell.2020.07.033. PMID:32783916 doi:http://dx.doi.org/10.1016/j.cell.2020.07.033
  7. Zhang L, Zhou R. Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase. J Phys Chem B. 2020 Aug 13;124(32):6955-6962. doi: 10.1021/acs.jpcb.0c04198. Epub, 2020 Jun 23. PMID:32521159 doi:http://dx.doi.org/10.1021/acs.jpcb.0c04198

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