STK11

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Serine/Threonine Kinase 11 complexed with STRADA and MO25 (PDB code 2wtk)

Contributors

Kelly Degnon, Stephanie Thai, Momo Sullivan, Kristen Zielinski, Chelsea Amagoh


References

  1. Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM. Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation. Science. 2009 Nov 5. PMID:19892943
  2. 2.0 2.1 2.2 Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban RH, Su GH. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol. 2003 Jul;16(7):686-91. PMID:12861065 doi:http://dx.doi.org/10.1097/01.MP.0000075645.97329.86
  3. Gartel AL. p21(WAF1/CIP1) and cancer: a shifting paradigm? Biofactors. 2009 Mar-Apr;35(2):161-4. doi: 10.1002/biof.26. PMID:19449443 doi:http://dx.doi.org/10.1002/biof.26
  4. Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature. 1998 Jan 8;391(6663):184-7. PMID:9428765 doi:10.1038/34432
  5. STK11. Genetics Home Reference. National Library of Medicine
  6. Gan RY, Li HB. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. International Journal of Molecular Science. 2014 Sep; 15(9):16698-16718.
  7. 7.0 7.1 Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W, Zimmer M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. 1998 Jan;18(1):38-43. PMID:9425897 doi:10.1038/ng0198-38
  8. Esteve-Puig R, Gil R, Gonzalez-Sanchez E, Bech-Serra JJ, Grueso J, Hernandez-Losa J, Moline T, Canals F, Ferrer B, Cortes J, Bastian B, Ramon Y Cajal S, Martin-Caballero J, Flores JM, Vivancos A, Garcia-Patos V, Recio JA. A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct 16;10(10):e1004721. doi: 10.1371/journal.pgen.1004721., eCollection 2014 Oct. PMID:25329316 doi:http://dx.doi.org/10.1371/journal.pgen.1004721

Proteopedia Page Contributors and Editors (what is this?)

Kelly Degnon, Michal Harel, Alexander Berchansky

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