Schubert lab: bacterial InIC disrupts human Tuba complexes

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Schubert lab: bacterial InlC disrupts human Tuba complexes

How this page was created

The goal of this page is to provide three-dimensional and interactive figures to explore the structures determined for the 2014 paper "Structural Details of Human Tuba Recruitment by Inlc of Listeria Monocytogenes Elucidate Bacterial Cell-Cell Spreading." by Polle, L., Rigano, L.A., Julian, R., Ireton, K., Schubert, W. published in Structure 22: 304-314.. The starting point are the figures found in this paper [1] . Biochemistry students at Westfield State University recreated these figures in jmol, and revised them after getting feedback from one of the authors, Prof. Wolf-Dieter Schubert [2], University of Pretoria, South Africa. A special thank you goes to Colleen R. Andrews, Kiley D. Baltazar, Caitlyn N. Blanchard, Frederick P. Brincklow, Naomi H. Cosmus, Nicole M. Craig, Albert B. Cuevas, Samantha M. Dominique, Carly Eaton, Courtney A. Finnigan, Kyle S. MacLaughlin, Shelby C. Mader, Vivian Pao, Tia C. Pariseau, Melanie R. Russo, Justin M. Schneider, Michelle G. Thornton, and Sarah J.Ward for making the initial figures and revising them. If you are interested to learn how these figures were created, take a look at the discussion page (2nd tab above).

Background

Listeria monocytogenes is a foodborne pathogen that can infect humans. The infection spreads from cell to cell when bacteria make their way through the junctional membrane. The Listeria protein InIC plays a role as a virulence factor by disrupting protein-protein interactions between the human protein Tuba or Dynamin-binding protein and its binding partners, resulting in a weakening of the actin cytoskeleton and increased success in infecting neighboring cells. The graphical abstract nicely summarizes how protein-protein interactions influence the virulence of Listeria. To get the full story with the benefit of the interactive 3D figures, study the research paper and explore the figures here on proteopedia.

Recreated figures

Caption for this structure

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Links to related information

Other structures associated with the Schubert lab: Schubert, W D

Proteopedia Page Contributors and Editors (what is this?)

Karsten Theis, Michal Harel, Joel L. Sussman

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