Serotonin Transporter

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Structure of the SERT Homologue LeuT, (2q6h)

3D structures of serotonin transporter

Updated on 03-October-2017

Page Development

This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University.

References

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  2. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996 Nov 29;274(5292):1527-31. PMID:8929413
  3. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007 Sep;10(9):1116-24. PMID:17726478 doi:10.1038/nn1944
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  7. Hyman SE. Neuroscience: obsessed with grooming. Nature. 2007 Aug 23;448(7156):871-2. PMID:17713517 doi:10.1038/448871a
  8. Singh SK, Yamashita A, Gouaux E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8. PMID:17687333 doi:10.1038/nature06038
  9. Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009 Jun;16(6):652-7. Epub 2009 May 10. PMID:19430461 doi:10.1038/nsmb.1602

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