Serum Paraoxonase

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PON1 - looking down 6-bladed propellers, Ca+2 (green) and phosphate (stick model) ions seen 1v04

3D structures of paraoxonase

1v04 – sPON + Ca + phosphate – synthetic
2vc7 – SsPON + thiophenium derivative + Co + Fe – Sulfolobus solfataricus
4kf1 – SsPON (mutant) + Co + Fe + thiophenium derivative
2vc5 – SsPON + Co + Fe
4ke4, 4kes, 4ket, 4keu, 4kev, 4kez – SsPON (mutant) + Co + Fe
4hho, 4hhq – sPON + Ca + Br
3sre – sPON + Ca + Br + phosphate
4q1u – sPON (mutant) + Ca + Br + phosphate
3srg – sPON + Ca + Br + oxoquinoline

References

  1. Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol. 2004 May;11(5):412-9. Epub 2004 Apr 18. PMID:15098021 doi:10.1038/nsmb767
  2. Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol. 2011 Feb;7(2):120-5. Epub 2011 Jan 9. PMID:21217689 doi:10.1038/nchembio.510
  3. Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J Mol Biol. 2013 Mar 25;425(6):1028-38. doi: 10.1016/j.jmb.2013.01.009. Epub 2013, Jan 11. PMID:23318950 doi:10.1016/j.jmb.2013.01.009
  4. Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS. Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1. J Mol Biol. 2012 Mar 1. PMID:22387469 doi:10.1016/j.jmb.2012.02.042

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Eran Hodis, Joel L. Sussman, Boris Brumshtein, Moshe Ben-David

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