Sonic Hedgehog

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Mouse sonic hedgehog complex with sulfate and Zn+2 ion (grey) (PDB code 1vhh)

3D Structures of sonic hedgehog

Updated on 09-February-2020

3m1n, 6pjv – hSHH N terminal – human
3ho5 – hSHH N terminal + hedgehog-interacting protein
3mxw – hSHH N terminal + antibody
6oev – hSHH N terminal + patched1
6dmy, 6n7g, 6n7h, 6n7k, 6rmg, 6rvd – hSHH N terminal + patched1 - Cryo EM
6e1h – hSHH N terminal + patched1 + palmitate - Cryo EM
1vhh, 3n1r – mSHH N terminal – mouse
3d1m – mSHH N terminal + cell adhesion molecule
2wfx, 2wg4 – mSHH N terminal + hedgehog-interacting protein
4c4m, 4c4n – mSHH N terminal + proteoglycan


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  2. Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30. PMID:7916661
  3. 3.0 3.1 Riddle RD, Johnson RL, Laufer E, Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 1993 Dec 31;75(7):1401-16. PMID:8269518
  4. 4.0 4.1 Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell. 1995 May 5;81(3):445-55. PMID:7736596
  5. Chuang PT, Kornberg TB. On the range of hedgehog signaling. Curr Opin Genet Dev. 2000 Oct;10(5):515-22. PMID:10980429
  6. 6.0 6.1 6.2 Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA. Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem. 2000 Apr 14;275(15):10995-1001. PMID:10753901
  7. Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003 Dec;3(12):903-11. PMID:14737121 doi:10.1038/nrc1229
  8. 8.0 8.1 8.2 Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer. 2002 May;2(5):361-72. PMID:12044012 doi:10.1038/nrc796
  9. Roessler E, Belloni E, Gaudenz K, Jay P, Berta P, Scherer SW, Tsui LC, Muenke M. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet. 1996 Nov;14(3):357-60. PMID:8896572 doi:10.1038/ng1196-357
  10. 10.0 10.1 Bumcrot DA, Takada R, McMahon AP. Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol. 1995 Apr;15(4):2294-303. PMID:7891723
  11. Porter JA, Young KE, Beachy PA. Cholesterol modification of hedgehog signaling proteins in animal development. Science. 1996 Oct 11;274(5285):255-9. PMID:8824192
  12. Pepinsky RB, Zeng C, Wen D, Rayhorn P, Baker DP, Williams KP, Bixler SA, Ambrose CM, Garber EA, Miatkowski K, Taylor FR, Wang EA, Galdes A. Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem. 1998 May 29;273(22):14037-45. PMID:9593755
  13. 13.0 13.1 13.2 13.3 13.4 13.5 13.6 Hall TM, Porter JA, Beachy PA, Leahy DJ. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 1995 Nov 9;378(6553):212-6. PMID:7477329 doi:
  14. 14.0 14.1 Bumcrot DA, McMahon AP. Sonic hedgehog: making the gradient. Chem Biol. 1996 Jan;3(1):13-6. PMID:8807822
  15. Placzek M, Jessell TM, Dodd J. Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development. 1993 Jan;117(1):205-18. PMID:8223247
  16. 16.0 16.1 16.2 Huangfu D, Anderson KV. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development. 2006 Jan;133(1):3-14. PMID:16339192 doi:133/1/3

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