T7 RNA Polymerase

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T7 RNA Polymerase Initiation Complex

Promoter bound polymerase (PDB code 1qln)

References

1,"1aro","Free enz plus lysozyme","T7RP with the bound inhibitor T7 lysozyme, no DNA - Jeruzalmi, D. & Steitz, T. A. (1998) EMBO J 17, 4101-4113"

2,"1cez","Enz with DNA bound (ED complex)","Early structure of T7RP with promo bound - Cheetham, G. M., Jeruzalmi, D. & Steitz, T. A. (1999) Nature 399, 80-83"

3,"2pi5","Enz with DNA bound (ED complex)","T7RP with promoter and first two NTPs bound - Kennedy, W.P.,††Momand, J.R.,††Yin, Y.W. (2007) Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase. J.Mol.Biol. 370: 256-268"

4,"2pi4","ED complex with GTP + GTP","T7RP with promoter and first two NTPs bound - Kennedy, W.P.,††Momand, J.R.,††Yin, Y.W. (2007) Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase. J.Mol.Biol. 370: 256-268"

5,"1qln","ED with 3mer RNA","T7RP with promoter DNA and GTP, allowing formation of a 3 base transcript - Cheetham, G. M. & Steitz, T. A. (1999) Science 286, 2305-2309",true

7,"3e2e","Initial complex at +7","The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation - Durniak, K.J., Bailey, S., Steitz, T.A. (2008) Science 322, 553-7"

6,"3e3j","Initial complex at +8","The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation - Durniak, K.J., Bailey, S., Steitz, T.A. (2008) Science 322, 553-7"

8,"1msw","Elongation complex (Steitz)","Elongation complex model formed with mismatch bubble DNA - Yin, Y. W. & Steitz, T. A. (2002). Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase. Science 298, 1387-1395."

9,"1h38","Elongation w scaffold","Elongation complex model formed by multi-piece scaffold - Tahirov, T. H., Temiakov, D., Anikin, M., Patlan, V., McAllister, W. T., Vassylyev, D. G. & Yokoyama, S. (2002) Nature 420, 43-50"

10,"1s0v","Elongation w ab-me-ATP","Scaffold elongation complex with non-hydrolyzable substrate NTP - Temiakov, D., Patlan, V., Anikin, M., McAllister, W. T., Yokoyama, S. & Vassylyev, D. G. (2004) Cell 116, 381-391"

11,"1s76","Elongation w ab-me-ATP","Mismatched bubble elongation complex with non-hydrolyzable substrate NTP - Yin, Y. W. & Steitz, T. A. (2004) Cell 116, 393-404"

12,"1s77","Elongation w PPi","Yin, Y. W. & Steitz, T. A. (2004) Cell 116, 393-404"

13,"4rnp","Low res free enz"


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