Thioredoxin Glutathione Reductase

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Thioredoxin glutathione reductase with cofactor FAD dimer complex with triethylene glycol 2x8c

3D Structures of Thioredoxin Glutathione Reductase

2v6o, 2x8c, 2x8g, 2x8h, 2xbi, 2xbq, 6ftc – SmTGR + FAD – Schistosoma mansoni
2x99 - SmTGR + FAD + NADPH
3h4k - SmTGR + FAD + auranofin
6rtj, 6rtm, 6rto - SmTGR+FAD + inhibitor
6fmu, 6fmz, 6fp4 - SmTGR + FAD + piperazine derivative
4la1 - TGR + FAD – Schistosoma japonicum
5w1j, 5w1l - TGR + FAD - Echinococcus granulosus


  1. Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec;1810(12):1262-71. doi:, 10.1016/j.bbagen.2011.06.024. Epub 2011 Jul 14. PMID:21782895 doi:
  2. Song L, Li J, Xie S, Qian C, Wang J, Zhang W, Yin X, Hua Z, Yu C. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS One. 2012;7(2):e31456. doi: 10.1371/journal.pone.0031456. Epub 2012 Feb 22. PMID:22384025 doi:
  3. Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography. J Biol Chem. 2010 Jul 21. PMID:20659890 doi:10.1074/jbc.M110.141960

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