Tobacco Etch Virus (TEV) Protease

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TEV protease catalytic domain (grey) complex with polypeptide substrate (pink) and acetate, 1lvm

3D structures of TEV protease

1q31 – TEV (mutant) – Tobacco etch virus
1lvb, 1lvm – TEV catalytic domain (mutant) + oligopeptide substrate

Additional Resources

For additional information, See: Viral Infections

References

  1. Ryan MD, Flint M. Virus-encoded proteinases of the picornavirus super-group. J Gen Virol. 1997 Apr;78 ( Pt 4):699-723. PMID:9129643
  2. Stanway G. Structure, function and evolution of picornaviruses. J Gen Virol. 1990 Nov;71 ( Pt 11):2483-501. PMID:2254747
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Phan J, Zdanov A, Evdokimov AG, Tropea JE, Peters HK 3rd, Kapust RB, Li M, Wlodawer A, Waugh DS. Structural basis for the substrate specificity of tobacco etch virus protease. J Biol Chem. 2002 Dec 27;277(52):50564-72. Epub 2002 Oct 10. PMID:12377789 doi:http://dx.doi.org/10.1074/jbc.M207224200
  4. 4.0 4.1 Yin J, Niu C, Cherney MM, Zhang J, Huitema C, Eltis LD, Vederas JC, James MN. A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase. J Mol Biol. 2007 Aug 24;371(4):1060-74. Epub 2007 Jun 8. PMID:17599357 doi:10.1016/j.jmb.2007.06.001
  5. Arad D, Kreisberg R, Shokhen M. Structural and mechanistic aspects of 3C proteases from the Picornavirus family. J Chem Inf Comput Sci. 1993 May-Jun;33(3):345-9. PMID:8320292
  6. Cleland WW, Frey PA, Gerlt JA. The low barrier hydrogen bond in enzymatic catalysis. J Biol Chem. 1998 Oct 2;273(40):25529-32. PMID:9748211
  7. 7.0 7.1 Cassidy CS, Lin J, Frey PA. A new concept for the mechanism of action of chymotrypsin: the role of the low-barrier hydrogen bond. Biochemistry. 1997 Apr 15;36(15):4576-84. PMID:9109667 doi:10.1021/bi962013o
  8. 8.0 8.1 8.2 Kapust RB, Tozser J, Copeland TD, Waugh DS. The P1' specificity of tobacco etch virus protease. Biochem Biophys Res Commun. 2002 Jun 28;294(5):949-55. PMID:12074568 doi:10.1016/S0006-291X(02)00574-0
  9. 9.0 9.1 Nunn CM, Jeeves M, Cliff MJ, Urquhart GT, George RR, Chao LH, Tscuchia Y, Djordjevic S. Crystal structure of tobacco etch virus protease shows the protein C terminus bound within the active site. J Mol Biol. 2005 Jul 1;350(1):145-55. PMID:15919091 doi:10.1016/j.jmb.2005.04.013
  10. Mohanty AK, Simmons CR, Wiener MC. Inhibition of tobacco etch virus protease activity by detergents. Protein Expr Purif. 2003 Jan;27(1):109-14. PMID:12509992
  11. Kapust RB, Tozser J, Fox JD, Anderson DE, Cherry S, Copeland TD, Waugh DS. Tobacco etch virus protease: mechanism of autolysis and rational design of stable mutants with wild-type catalytic proficiency. Protein Eng. 2001 Dec;14(12):993-1000. PMID:11809930
  12. Gorbalenya AE, Blinov VM, Donchenko AP. Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families. FEBS Lett. 1986 Jan 6;194(2):253-7. PMID:3000829

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