Hydroxylase

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Human phenylalanine hydroxylase catalytic domain containing Fe+3 ion (orange) (PDB entry 1pah)

3D structures of hydroxylases

Updated on 18-July-2018

Additional Resources

For additional information, see: Amino Acid Synthesis & Metabolism

References

  1. Fitzpatrick PF. The aromatic amino acid hydroxylases. Adv Enzymol Relat Areas Mol Biol. 2000;74:235-94. PMID:10800597
  2. KAUFMAN S. The enzymatic conversion of phenylalanine to tyrosine. J Biol Chem. 1957 May;226(1):511-24. PMID:13428782
  3. Chen D, Frey PA. Phenylalanine hydroxylase from Chromobacterium violaceum. Uncoupled oxidation of tetrahydropterin and the role of iron in hyroxylation. J Biol Chem. 1998 Oct 2;273(40):25594-601. PMID:9748224
  4. Leiros HK, Pey AL, Innselset M, Moe E, Leiros I, Steen IH, Martinez A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. J Biol Chem. 2007 Jul 27;282(30):21973-86. Epub 2007 May 30. PMID:17537732 doi:10.1074/jbc.M610174200
  5. Grenett HE, Ledley FD, Reed LL, Woo SL. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5530-4. PMID:3475690
  6. NAGATSU T, LEVITT M, UDENFRIEND S. TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS. J Biol Chem. 1964 Sep;239:2910-7. PMID:14216443
  7. 7.0 7.1 LEVINE RJ, LOVENBERG W, SJOERDSMA A. HYDROXYLATION OF TRYPTOPHAN AND PHENYLALANINE IN NEOPLASTIC MAST CELLS OF THE MOUSE. Biochem Pharmacol. 1964 Sep;13:1283-90. PMID:14221726
  8. Grahame-Smith DG. Tryptophan hydroxylation in brain. Biochem Biophys Res Commun. 1964 Aug 11;16(6):586-92. PMID:5297063
  9. 9.0 9.1 Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol. 2003 Nov 1;66(9):1673-80. PMID:14563478
  10. Grenett HE, Ledley FD, Reed LL, Woo SL. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5530-4. PMID:3475690
  11. Craig SP, Boularand S, Darmon MC, Mallet J, Craig IW. Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3----p14 by in situ hybridization. Cytogenet Cell Genet. 1991;56(3-4):157-9. PMID:2055111
  12. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003 Jan 3;299(5603):76. PMID:12511643 doi:http://dx.doi.org/10.1126/science.1078197
  13. 13.0 13.1 Patel PD, Pontrello C, Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry. 2004 Feb 15;55(4):428-33. PMID:14960297 doi:http://dx.doi.org/10.1016/j.biopsych.2003.09.002
  14. Slominski A, Pisarchik A, Johansson O, Jing C, Semak I, Slugocki G, Wortsman J. Tryptophan hydroxylase expression in human skin cells. Biochim Biophys Acta. 2003 Oct 15;1639(2):80-6. PMID:14559114
  15. Hasegawa H, Yanagisawa M, Inoue F, Yanaihara N, Ichiyama A. Demonstration of non-neural tryptophan 5-mono-oxygenase in mouse intestinal mucosa. Biochem J. 1987 Dec 1;248(2):501-9. PMID:3435461
  16. Hosoda S, Nakamura W, Takatsuki K. Properties of tryptophan hydroxylase from human carcinoid tumor. Biochim Biophys Acta. 1977 May 12;482(1):27-34. PMID:16654
  17. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry. 1999 Mar 1;45(5):603-14. PMID:10088047
  18. Mitchell JJ, Trakadis YJ, Scriver CR. Phenylalanine hydroxylase deficiency. Genet Med. 2011 Aug;13(8):697-707. doi: 10.1097/GIM.0b013e3182141b48. PMID:21555948 doi:http://dx.doi.org/10.1097/GIM.0b013e3182141b48
  19. Flatmark T, Stevens RC. Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms. Chem Rev. 1999 Aug 11;99(8):2137-2160. PMID:11849022

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