Tubulin

From Proteopedia

Contents 1 Function 2 Relevance 3 Disease 4 Structural highlights 5 3D Structures of Tubulin Function Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules[1]. Human TUB contains several numbered subtypes. Tubulin filaments are stabilized by taxol and zampanolide. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB[2]. See Cell division protein and Beta tubulin. Relevance The chemotherapeutic drug Taxol interacts with TUBB. See Molecular Playground/Taxol. TUBA and TUBB expression in polyps of invasive colon cancer is different from normal[3]. See Paclitaxel. Disease Mutations in TUBB underlie a large spectrum of neuronal migration disorders[4]. Structural highlights γ-tubulin interactions with GTP and Mg+2 ion (1z5w). 3D Structures of Tubulin Tubulin 3D Structures

spinqualitylabelsall models γ-tubulin complex with GTP and Mg+2 ion (green), 1z5w Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Moritz M, Agard DA. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr;11(2):174-81. PMID:11297925
2. ↑ Arjes HA, Lai B, Emelue E, Steinbach A, Levin PA. Mutations in the bacterial cell division protein FtsZ highlight the role of GTP binding and longitudinal subunit interactions in assembly and function. BMC Microbiol. 2015 Oct 13;15:209. doi: 10.1186/s12866-015-0544-z. PMID:26463348 doi:http://dx.doi.org/10.1186/s12866-015-0544-z
3. ↑ Giarnieri E, De Francesco GP, Carico E, Midiri G, Amanti C, Giacomelli L, Tucci G, Gidaro S, Stroppa I, Gidaro G, Giovagnoli MR. Alpha- and beta-tubulin expression in rectal cancer development. Anticancer Res. 2005 Sep-Oct;25(5):3237-41. PMID:16101133
4. ↑ Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phan-Dinh-Tuy F, Kong XP, Bomont P, Castelnau-Ptakhine L, Odent S, Loget P, Kossorotoff M, Snoeck I, Plessis G, Parent P, Beldjord C, Cardoso C, Represa A, Flint J, Keays DA, Cowan NJ, Chelly J. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet. 2009 Jun;41(6):746-52. doi: 10.1038/ng.380. Epub 2009 May 24. PMID:19465910 doi:http://dx.doi.org/10.1038/ng.380