Tyrosine kinase

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Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model complex with inhibitor staurosporine (PDB code 2dq7).

3D structures of tyrosine kinase

Updated on 13-February-2019

  1. Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annu Rev Biochem. 2000;69:373-98. PMID:10966463 doi:http://dx.doi.org/10.1146/annurev.biochem.69.1.373
  2. Roskoski R Jr. Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1155-64. PMID:15504335 doi:http://dx.doi.org/10.1016/j.bbrc.2004.09.171
  3. Tolomeo M, Dieli F, Gebbia N, Simoni D. Tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia. Anticancer Agents Med Chem. 2009 Oct;9(8):853-63. PMID:19538165
  4. Lengyel E, Sawada K, Salgia R. Tyrosine kinase mutations in human cancer. Curr Mol Med. 2007 Feb;7(1):77-84. PMID:17311534
  5. Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T. Structure of human Fyn kinase domain complexed with staurosporine. Biochem Biophys Res Commun. 2006 Aug 4;346(3):840-4. Epub 2006 Jun 13. PMID:16782058 doi:10.1016/j.bbrc.2006.05.212
  6. Tou WI, Chen CY. Traditional Chinese medicine as dual guardians against hypertension and cancer? J Biomol Struct Dyn. 2012 Jul;30(3):299-317. Epub 2012 Jun 12. PMID:22694277 doi:10.1080/07391102.2012.680030

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