Urease

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Urease α (pink), β (green), γ (grey) chains complex with citrate, sulfate and Ni+2 ions (green) (PDB code 4ac7)

3D structures of urease

Updated on 13-October-2017

Additional Resources

For additional information on Urinary Tract Infection, See: 1tr7
For additional information on Helicobacter Pylori, See: 1e9z

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 PMID: PMC2443974
  2. http://www.jbc.org/content/277/35/e23.full?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1130442887043_7599&stored_search=&FIRSTINDEX=60&tocsectionid=Classics&sortspec=PUBDATE_SORTDATE+desc
  3. Andrews, R. K., Blakeley, R. L. & Zerner, B. (1984). Urea and urease. Adv. Inorg. Biochem. 6, 245–283.
  4. Dixon, N. E., Riddles, P. W., Gazzola, C., Blakeley, R. L. & Zerner, B. (1980). Jack been urease (EC 3.5.1.5). II. The relationship between nickel, enzymatic activity, and the “abnormal” ultraviolet spectrum. The nickel content of jack beans. Can. J. Biochem. 58, 474–480.
  5. Moncrief, M. C. & Hausinger, R. P. (1996). Nickel incorporation into urease. In Mechanisms of Metallo- center Assembly (Hausinger, R. P., Eichhorn, G. L. & Marzilli, L. G., eds), pp. 151–171, Elsevier Press, New York, NY.
  6. 6.0 6.1 Covacci, A., Telford, J. L., Del Giudice, G., Parsonnet, J. & Rappuoli, R. (1999). Helicobacter pylori virulence and genetic geography. Science, 284, 1328–1333.
  7. Polacco, J. C. & Holland, M. A. (1993). Roles of urease in plant cells. Int. Rev. Cytol. 145, 65–103.
  8. 8.0 8.1 http://en.wikipedia.org/wiki/Urease
  9. 9.0 9.1 9.2 Mobley, H. L. T., Island, M. D. & Hausinger, R. P. (1995). Molecular biology of microbial ureases. Microbiol. Rev. 59, 451–480.
  10. http://www.cell.com/structure/abstract/S0969-2126(99)80026-4#.
  11. Cicmanec JF, Helmers SL, Evans AT. Office practice survey of urease positive bacterial pathogens causing urinary tract infections. Urology. 1980 Sep;16(3):274-6. PMID:6999699
  12. Dixon, N. E., Riddles, P. W., Gazzola, C., Blakeley, R. L. & Zerner, B. (1980). Jack been urease (EC 3.5.1.5). II. The relationship between nickel, enzymatic activity, and the “abnormal” ultraviolet spectrum. The nickel content of jack beans. Can. J. Biochem. 58, 474–480.
  13. Becker-Ritt, A. B., Martinelli, A. H. S., Mitidieri, S., Feder, V., Wassermann, G. E., Santi, L. et al. (2007). Antifungal activity of plant and bacterial ureases. Toxicon, 50, 971–983.
  14. 14.0 14.1 Follmer, C., Real-Guerra, R., Wassermann, G. E., Olivera-Severo, D. & Carlini, C. R. (2004). Jackbean, soybean and Bacillus pasteurii ureases—biological effects unrelated to ureolytic activity. Eur. J. Biochem. 271, 1357–1363.
  15. Karplus, P. A., Pearson, M. A. & Hausinger, R. P. (1997). 70 years of crystalline urease: what have we learnt? Acc. Chem. Res. 30, 330–337.
  16. Benini, S., Rypneiwski, W. R., Wilson, K. S., Meletti, S., Ciurli, S. & Mangani, S. (1999). A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels. Structure, 7, 205–216.
  17. 17.0 17.1 http://tonga.usip.edu/jsnow/chem348/recitation8.pdf
  18. http://emedicine.medscape.com/article/1174503-overview
  19. http://www.nucdf.org/ucd_treatment.htm
  20. Benini S, Kosikowska P, Cianci M, Mazzei L, Vara AG, Berlicki L, Ciurli S. The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design. J Biol Inorg Chem. 2013 Mar;18(3):391-9. doi: 10.1007/s00775-013-0983-7. Epub, 2013 Feb 15. PMID:23412551 doi:10.1007/s00775-013-0983-7
  21. Kcx - Lysine NZ-carboxylic acid
  22. Zambelli B, Banaszak K, Merloni A, Kiliszek A, Rypniewski W, Ciurli S. Selectivity of Ni(II) and Zn(II) binding to Sporosarcina pasteurii UreE, a metallochaperone in the urease assembly: a calorimetric and crystallographic study. J Biol Inorg Chem. 2013 Dec;18(8):1005-17. doi: 10.1007/s00775-013-1049-6. Epub, 2013 Oct 15. PMID:24126709 doi:http://dx.doi.org/10.1007/s00775-013-1049-6
  23. Ligabue-Braun R, Real-Guerra R, Carlini CR, Verli H. Evidence-based docking of the urease activation complex. J Biomol Struct Dyn. 2012 Sep 10. PMID:22962938 doi:10.1080/07391102.2012.713782
  24. Benini S, Cianci M, Mazzei L, Ciurli S. Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics. J Biol Inorg Chem. 2014 Aug 12. PMID:25113581 doi:http://dx.doi.org/10.1007/s00775-014-1182-x

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