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The Human Histone Deacetylase, HDAC8

HDAC8, PDB:2v5w


  1. 1.0 1.1 Histones | Learn Science at Scitable
  2. What is chromatin, heterochromatin and euchromatin? MBInfo
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Vannini A, Volpari C, Gallinari P, Jones P, Mattu M, Carfi A, De Francesco R, Steinkuhler C, Di Marco S. Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. EMBO Rep. 2007 Sep;8(9):879-84. Epub 2007 Aug 10. PMID:17721440
  4. Seto E, Yoshida M. Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a018713. doi:, 10.1101/cshperspect.a018713. PMID:24691964 doi:
  5. Chen K, Zhang X, Wu YD, Wiest O. Inhibition and mechanism of HDAC8 revisited. J Am Chem Soc. 2014 Aug 20;136(33):11636-43. doi: 10.1021/ja501548p. Epub 2014, Aug 7. PMID:25060069 doi:
  6. Tabackman AA, Frankson R, Marsan ES, Perry K, Cole KE. Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket. J Struct Biol. 2016 Sep;195(3):373-8. doi: 10.1016/j.jsb.2016.06.023. Epub 2016, Jun 29. PMID:27374062 doi:
  7. 7.0 7.1 Marks PA. Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):717-25. doi:, 10.1016/j.bbagrm.2010.05.008. Epub 2010 Jun 8. PMID:20594930 doi:
  8. Vannini A, Volpari C, Filocamo G, Casavola EC, Brunetti M, Renzoni D, Chakravarty P, Paolini C, De Francesco R, Gallinari P, Steinkuhler C, Di Marco S. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15064-9. Epub 2004 Oct 11. PMID:15477595

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  • Courtney Brown
  • Cassandra Marsh
  • Carolyn Hurdle

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Courtney Brown

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