User:Krishna Reddy Ragupathi

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

Carbonic Anhydrase

Shown is the enzyme Carbonic Anhydrase II which falls under α-Family of Carbonic Anhydrases. As the name suggest Carbonic Anhydrases are a class of enzymes which catalyze the reversible conversion of carbondioxide to the bicarbonate and proton. Due to this unique property they play a key role in maintaining the acid-base balance of blood and several other tissues.


The active site of the enzyme is depicted here, which has three histidine residues coordinated to the zinc metal.

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Krishna Reddy Ragupathi, Eran Hodis

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