User:Neal Hayhurst/RNA Polymerase II/Sandbox 1

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Yeast RNA Polymerase II complex with RNA (PDB code 1i6h)

References

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  24. doi/10.1101/gad.1055503
  25. Shah N, Maqbool MA, Yahia Y, El Aabidine AZ, Esnault C, Forne I, Decker TM, Martin D, Schuller R, Krebs S, Blum H, Imhof A, Eick D, Andrau JC. Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals. Mol Cell. 2018 Jan 4;69(1):48-61.e6. doi: 10.1016/j.molcel.2017.12.009. PMID:29304333 doi:http://dx.doi.org/10.1016/j.molcel.2017.12.009
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Alpha-aminitin chemical structure image courtesy of https://en.wikipedia.org/wiki/Alpha-Amanitin#/media/File:Alpha-amanitin_structure.png

Notes

From structural components:

Structural overview: [PDB: 5VVR: with highlighted sections mentioned below]

Bridge: Depicted: [PDB: 1I6H: 810-845.a]

Wall: Depicted: [PDB: 1R5U: 853-919.b; 933-972.b]

Clamp: Depicted: [PDB: 1R5U: 3-345.a; 1395-1435.a; 1158-1124.b]

Rudder: Depicted: [PDB: 5VVR: 306-321.a]


Content Donators

This page was created as a final project for the Advanced Biochemistry course at Wabash College during the Fall of 2019 and Fall of 2020. This page was reviewed by Dr. Wally Novak of Wabash College.

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Neal Hayhurst

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