First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
1yt7
From Proteopedia
| 1yt7, resolution 2.30Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||||
| Gene: | CTSK, CTSO, CTSO2 (Homo sapiens) | ||||||||
| Activity: | Cathepsin K, with EC number 3.4.22.38 | ||||||||
| Related: | 1tu6 | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Cathepsin K complexed with a constrained ketoamide inhibitor
An orally bioavailable series of ketoamide-based cathepsin K inhibitors with good pharmacokinetic properties has been identified. Starting from a potent inhibitor endowed with poor drug properties, conformational constraint of the P(2)-P(3) linker and modifications to P(1') elements led to an enhancement in potency, solubility, clearance, and bioavailability. These optimized inhibitors attenuated bone resorption in a rat TPTX hypocalcemic bone resorption model.
P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K., Barrett DG, Boncek VM, Catalano JG, Deaton DN, Hassell AM, Jurgensen CH, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA, Ray JA, Samano V, Shewchuk LM, Tavares FX, Wells-Knecht KJ, Willard DH Jr, Wright LL, Zhou HQ, Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. PMID:15982880
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1yt7 is a 1 chain structure of Cathepsin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Barrett DG, Boncek VM, Catalano JG, Deaton DN, Hassell AM, Jurgensen CH, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA, Ray JA, Samano V, Shewchuk LM, Tavares FX, Wells-Knecht KJ, Willard DH Jr, Wright LL, Zhou HQ. P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. PMID:15982880 doi:10.1016/j.bmcl.2005.05.062
Categories: Cathepsin K | Homo sapiens | Barrett, D G. | Boncek, V M. | Catalano, J G. | Deaton, D N. | Hassell, A M. | Jurgensen, C H. | Long, S T. | McFadyen, R B. | Miller, A B. | Miller, L R. | Payne, J A. | Ray, J A. | Samano, V. | Shewchuk, L M. | Tavares, F X. | Wells-Knecht, K J. | Willard, D H. | Wright, L L. | Zhou, H Q. | Cathepsin | Cysteine protease | Hydrolase
