Kemp eliminase

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Designed kemp eliminase KE59 complex with phosphate (PDB code 3uxa)

See also

3D structures of Kemp eliminase

Updated on 08-September-2019

References

  • Khersonsky O, Rothlisberger D, Dym O, Albeck S, Jackson CJ, Baker D, Tawfik DS. Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series. J Mol Biol. 2010 Mar 5;396(4):1025-42. Epub 2009 Dec 28. PMID:20036254 doi:10.1016/j.jmb.2009.12.031
  • Rothlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Kemp elimination catalysts by computational enzyme design. Nature. 2008 May 8;453(7192):190-5. Epub 2008 Mar 19. PMID:18354394 doi:10.1038/nature06879
  • Khersonsky O, Kiss G, Rothlisberger D, Dym O, Albeck S, Houk KN, Baker D, Tawfik DS. Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59. Proc Natl Acad Sci U S A. 2012 Jun 8. PMID:22685214 doi:10.1073/pnas.1121063109

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