Carbonyl reductase (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase.
- (R)-specific carbonyl reductase yields (R)-alcohols and its cofactor is Zn+2 ion.[1]
- Active site of mouse carbonyl reductase (1cyd).[2]
3D structures of carbonyl reductase
Carbonyl reductase 3D structures
- ↑ Forrest GL, Gonzalez B. Carbonyl reductase. Chem Biol Interact. 2000 Dec 1;129(1-2):21-40. PMID:11154733
- ↑ Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure. 1996 Jan 15;4(1):33-45. PMID:8805511
