11lq

Human monoclonal antibodies 4C12 and 4H3 in complex with rabies virus glycoprotein

spinqualitylabelsall models 11lq, resolution 3.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 11lq is a 21 chain structure with sequence from Homo sapiens and Rabies lyssavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.24Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GLYCO_RABVP Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).

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