1gwc

The structure of a tau class glutathione S-transferase from wheat, active in herbicide detoxification

spinqualitylabelsall models 1gwc, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1gwc is a 3 chain structure with sequence from Aegilops tauschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.25Å Ligands: GTX, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O04941_AEGTA Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Glutathione S-transferases (GSTs) from the phi (GSTF) and tau (GSTU) classes are unique to plants and play important roles in stress tolerance and secondary metabolism as well as catalyzing the detoxification of herbicides in crops and weeds. We have cloned and functionally characterized a group of GSTUs from wheat treated with fenchlorazole-ethyl, a herbicide safener. One of these enzymes, TaGSTU4-4, was highly active in conjugating the chemically distinct wheat herbicides fenoxaprop and dimethenamid. The structure of TaGSTU4-4 has been determined at 2.2 A resolution in complex with S-hexylglutathione. This enzyme is the first tau class GST structure to be determined and most closely resembles the omega class GSTs, but without the unique N-terminal extension or active site cysteine. The X-ray structure identifies key amino acid residues in the hydrophobic binding site and provides insights into the substrate specificity of these enzymes. Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification.,Thom R, Cummins I, Dixon DP, Edwards R, Cole DJ, Lapthorn AJ Biochemistry. 2002 Jun 4;41(22):7008-20. PMID:12033934 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glutathione S-transferase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA