1kgs

Crystal Structure at 1.50 A of an OmpR/PhoB Homolog from Thermotoga maritima

spinqualitylabelsall models 1kgs, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1kgs is a 1 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: MSE, SCN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9WYN0_THEMA Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Two-component systems, the predominant signal transduction strategy used by prokaryotes, involve phosphorelay from a sensor histidine kinase (HK) to an intracellular response regulator protein (RR) that typically acts as a transcription regulator. RRs are modular proteins, usually composed of a conserved regulatory domain, which functions as a phosphorylation-activated switch, and an attached DNA binding effector domain. The crystal structure of a Thermotoga maritima transcription factor, DrrD, has been determined at 1.5 A resolution, providing the first structural information for a full-length member of the OmpR/PhoB subfamily of RRs. A small interdomain interface occurs between alpha 5 of the regulatory domain and an antiparallel sheet of the effector domain. The lack of an extensive interface in the unphosphorylated protein distinguishes DrrD from other structurally characterized multidomain RRs and suggests a different mode of interdomain regulation. Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima.,Buckler DR, Zhou Y, Stock AM Structure. 2002 Feb;10(2):153-64. PMID:11839301 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Response regulator Response regulator 3D structure

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