1ujy

Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6

spinqualitylabelsall models 1ujy Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1ujy is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Disease ARHG6_HUMAN Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:300436. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Function ARHG6_HUMAN Acts as a RAC1 guanine nucleotide exchange factor (GEF). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Rho guanine nucleotide exchange factor 3D structures

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