1xbr

T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA

spinqualitylabelsall models 1xbr, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1xbr is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TBXT_XENLA Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation (PubMed:11869292). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (PubMed:11111039). Causes dorsal mesodermal differentiation of animal cap ectoderm when co-expressed with wnt8 and noggin (PubMed:7906224). None of these molecules causes dorsal mesoderm formation when expressed alone (PubMed:7906224). Establishes the left/right axis at early gastrula stage by directly up-regulating mesodermal expression of zic3 (PubMed:11869292). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Brachyury

Proteopedia Page Contributors and Editors (what is this?)

OCA