4v51

Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin

spinqualitylabelsall models 4v51, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v51 is a 20 chain structure with sequence from Thermus thermophilus HB8. This structure supersedes the now removed PDB entries 2j00, 2j01, 2j02 and 2j03. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8Å Ligands: 5MU, MG, PAR, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RS2_THET8 Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B] Publication Abstract from PubMed The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation. Structure of the 70S ribosome complexed with mRNA and tRNA.,Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Large Ribosomal Subunit of Haloarcula Ribosomal protein THX 3D structures Ribosome 3D structures Transfer RNA (tRNA)

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