2j91 | pdb_00002j91

Crystal structure of Human Adenylosuccinate Lyase in complex with AMP

spinqualitylabelsall models 2j91, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2j91 is a 4 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2j84. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: AMP, CL, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease PUR8_HUMAN Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency) [MIM:103050. ADSL deficiency is an autosomal recessive disorder characterized by the accumulation in the body fluids of succinylaminoimidazole-carboxamide riboside (SAICA-riboside) and succinyladenosine (S-Ado). Most children display marked psychomotor delay, often accompanied by epilepsy or autistic features, or both, although some patients may be less profoundly retarded. Occasionally, growth retardation and muscular wasting are also present. Function PUR8_HUMAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Adenylosuccinate lyase 3D structures

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