2xbo

Equine Rhinitis A Virus in Complex with its Sialic Acid Receptor

spinqualitylabelsall models 2xbo, resolution 4.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2xbo is a 4 chain structure with sequence from Equine rhinitis A virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 4Å Ligands: GAL, GLC, PRD_900025, SIA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B9VV85_9PICO Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Equine rhinitis A virus (ERAV) shares many features with foot-and-mouth disease virus (FMDV) and both are classified within the genus Aphthovirus of the family Picornaviridae. ERAV is used as a surrogate for FMDV research as it does not require high-level biosecurity. In contrast to FMDV, which uses integrins as cellular receptors, the receptor for ERAV has been reported to involve the sugar moiety sialic acid. This study confirmed the importance of sialic acid for cell entry by ERAV and reports the crystal structure of ERAV particles complexed with the receptor analogue 3'-sialyllactose. The receptor is attached to the rim of a capsid pit adjacent to the major immunogenic site and distinct from the sialic acid binding site used by a related picornavirus, the cardiovirus Theiler's murine encephalitis virus. The structure of the major antigenic determinant of the virus, previously identified from antibody escape mutations, is also described as the EF loop of VP1, which forms a hairpin stretching across the capsid surface close to the icosahedral fivefold axis, neighbouring the receptor-binding site, and spanning two protomeric units. Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.,Fry EE, Tuthill TJ, Harlos K, Walter TS, Rowlands DJ, Stuart DI J Gen Virol. 2010 Aug;91(Pt 8):1971-7. Epub 2010 Apr 28. PMID:20427563 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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