Structural highlights
Function
PILP_PSEAE Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus (PubMed:19857645). PilP connects PilO to the secretin PilQ. In turn, the PilM/PilN/PilO/PilP/PilQ complex facilitates transit of the pilus through the periplasm and clamps the pilus in the cell envelope (PubMed:23457250).[1] [2]
References
- ↑ Ayers M, Sampaleanu LM, Tammam S, Koo J, Harvey H, Howell PL, Burrows LL. PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin. J Mol Biol. 2009 Nov 20;394(1):128-42. PMID:19857645 doi:10.1016/j.jmb.2009.09.034
- ↑ Tammam S, Sampaleanu LM, Koo J, Manoharan K, Daubaras M, Burrows LL, Howell PL. PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. J Bacteriol. 2013 May;195(10):2126-35. PMID:23457250 doi:10.1128/JB.00032-13
