3duz

Crystal structure of the postfusion form of baculovirus fusion protein GP64

spinqualitylabelsall models 3duz, resolution 2.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3duz is a 1 chain structure with sequence from Autographa californica nucleopolyhedrovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.95Å Ligands: HG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function FUS_NPVAC Envelope phosphoglycoprotein which mediates the fusion of viral and host endosomal membranes leading to virus entry into the host cell. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Viral fusion proteins mediate the merger of host and viral membranes during cell entry for all enveloped viruses. Baculovirus glycoprotein gp64 (gp64) is unusual in promoting entry into both insect and mammalian cells and is distinct from established class I and class II fusion proteins. We report the crystal structure of its postfusion form, which explains a number of gp64's biological properties including its cellular promiscuity, identifies the fusion peptides and shows it to be the third representative of a new class (III) of fusion proteins with unexpected structural homology with vesicular stomatitis virus G and herpes simplex virus type 1 gB proteins. We show that domains of class III proteins have counterparts in both class I and II proteins, suggesting that all these viral fusion machines are structurally more related than previously thought. The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines.,Kadlec J, Loureiro S, Abrescia NG, Stuart DI, Jones IM Nat Struct Mol Biol. 2008 Oct;15(10):1024-30. Epub 2008 Sep 7. PMID:18776902 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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