5v00 | pdb_00005v00

Structure of HutD from Pseudomonas fluorescens SBW25 (Formate condition)

spinqualitylabelsall models 5v00, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5v00 is a 2 chain structure with sequence from Pseudomonas fluorescens SBW25. This structure supersedes the now removed PDB entry 3esg. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: FMT, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C3K802_PSEFS Publication Abstract from PubMed Cupins form one of the most functionally diverse superfamilies of proteins, with members performing a wide range of catalytic, non-catalytic, and regulatory functions. HutD is a predicted bicupin protein that is involved in histidine utilization (Hut) in Pseudomonas species. Previous genetic analyses have suggested that it limits the upper level of Hut pathway expression, but its mechanism of action is unknown. Here, we have determined the structure of PfluHutD at 1.74 A resolution in several crystallization conditions, and identified N-formyl-L-glutamate (a Hut pathway intermediate) is a potential ligand in vivo. This article is protected by copyright. All rights reserved. Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.,Gerth ML, Liu Y, Jiao W, Zhang XX, Baker EN, Lott JS, Rainey PB, Johnston JM Proteins. 2017 Apr 6. doi: 10.1002/prot.25303. PMID:28383128 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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