4q4y

Crystal structure of Coxsackievirus A24v soaked with Disialyllacto-N-tetraose (DSLNT)

spinqualitylabelsall models 4q4y, resolution 1.88Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4q4y is a 4 chain structure with sequence from Coxsackievirus A24. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.88Å Ligands: CA, CL, HEZ, MG, MYR, SIA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function V9VEF3_9ENTO Publication Abstract from PubMed The picornaviruses coxsackievirus A24 variant (CVA24v) and enterovirus 70 (EV70) cause continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC), a highly contagious eye disease against which neither vaccines nor antiviral drugs are currently available. Moreover, these viruses can cause symptoms in the cornea, upper respiratory tract, and neurological impairments such as acute flaccid paralysis. EV70 and CVA24v are both known to use 5-N-acetylneuraminic acid (Neu5Ac) for cell attachment, thus providing a putative link between the glycan receptor specificity and cell tropism and disease. We report the structures of an intact human picornavirus in complex with a range of glycans terminating in Neu5Ac. We determined the structure of the CVA24v to 1.40 A resolution, screened different glycans bearing Neu5Ac for CVA24v binding, and structurally characterized interactions with candidate glycan receptors. Biochemical studies verified the relevance of the binding site and demonstrated a preference of CVA24v for alpha2,6-linked glycans. This preference can be rationalized by molecular dynamics simulations that show that alpha2,6-linked glycans can establish more contacts with the viral capsid. Our results form an excellent platform for the design of antiviral compounds to prevent AHC. A sialic Acid binding site in a human picornavirus.,Zocher G, Mistry N, Frank M, Hahnlein-Schick I, Ekstrom JO, Arnberg N, Stehle T PLoS Pathog. 2014 Oct 16;10(10):e1004401. doi: 10.1371/journal.ppat.1004401., eCollection 2014 Oct. PMID:25329320 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat proteins 3D structures

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