4v7m

The structures of Capreomycin bound to the 70S ribosome.

spinqualitylabelsall models 4v7m, resolution 3.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v7m is a 20 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.45Å Ligands: DPP, KBE, MG, MYN, UAL, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RS10_THET8 Part of the top of the 30S subunit head.[HAMAP-Rule:MF_00508] Publication Abstract from PubMed Viomycin and capreomycin belong to the tuberactinomycin family of antibiotics, which are among the most effective antibiotics against multidrug-resistant tuberculosis. Here we present two crystal structures of the 70S ribosome in complex with three tRNAs and bound to either viomycin or capreomycin at 3.3- and 3.5-A resolution, respectively. Both antibiotics bind to the same site on the ribosome, which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of these complexes suggest that the tuberactinomycins inhibit translocation by stabilizing the tRNA in the A site in the pretranslocation state. In addition, these structures show that the tuberactinomycins bind adjacent to the binding sites for the paromomycin and hygromycin B antibiotics, which may enable the development of new derivatives of tuberactinomycins that are effective against drug-resistant strains. The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.,Stanley RE, Blaha G, Grodzicki RL, Strickler MD, Steitz TA Nat Struct Mol Biol. 2010 Mar;17(3):289-93. Epub 2010 Feb 14. PMID:20154709 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosomal protein THX 3D structures Ribosome 3D structures Transfer RNA (tRNA)

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