4wm7

Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril

spinqualitylabelsall models 4wm7, resolution 2.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wm7 is a 4 chain structure with sequence from Enterovirus D68. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.32Å Ligands: W11 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9YLJ3_HED68 Publication Abstract from PubMed Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks. Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat proteins 3D structures

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