4zk3

Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. Low pH structure

spinqualitylabelsall models 4zk3, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4zk3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SPB3_HUMAN May act as a protease inhibitor to modulate the host immune response against tumor cells. Publication Abstract from PubMed Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but not in uninvolved skin. We recently demonstrated that the Pso p27 is generated by cleavage of SerpinB3 (SCCA1) in the presence of mast cell associated chymase. In this communication we demonstrate by X-ray crystallographic analysis that the cleavage products associate into a complex similar to SCCA1, but with the reactive centre loop inserted into a 5-stranded central beta-sheet. Native gel electrophoresis show that these Pso p27 complexes form large aggregates which may be of significance with respect to an immunogenic role of Pso p27. Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.,Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ Biochem Biophys Rep. 2015 Jun 9;2:132-136. doi: 10.1016/j.bbrep.2015.06.001., eCollection 2015 Jul. PMID:29124154 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Serpin 3D structures

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