5h5z

Crystal structure of bony fish MHC class I, peptide and B2m II

spinqualitylabelsall models 5h5z, resolution 1.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5h5z is a 3 chain structure with sequence from Carp sprivivirus and Ctenopharyngodon idella. This structure supersedes the now removed PDB entry 5cnz. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.74Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q65XY8_CTEID Publication Abstract from PubMed Contemporary antigen presentation knowledge is based on the existence of a single beta2m locus, and a classical MHC class I forms a complex with a peptide (i.e., pMHC-I) to trigger CTL immunity. However, two beta2m loci have been found in diploid bony fish; the function of the two beta2m molecules is unclear. Here, we determined the variant peptide profiles originating from different products of the beta2m loci binding to the same MHC-I molecule and further solved the crystal structures of the two pMHC-I molecules (i.e., pCtid-UAA-beta2m-2 and pCtid-UAA-beta2m-1-II). Of note, in pCtid-UAA-beta2m-2, a unique hydrogen bond network formed in the bottom of the peptide-binding groove (PBG) led to alpha2-helix drift, ultimately leading to structural changes in the PBG. The mechanism of the change in peptide presentation profiles by beta2m molecules is illustrated. The results are also of great significance for antivirus and antitumor functions in cold-blooded vertebrates and even humans. The Mechanism of beta2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.,Li Z, Zhang N, Ma L, Zhang L, Meng G, Xia C iScience. 2020 May 22;23(5):101119. doi: 10.1016/j.isci.2020.101119. Epub 2020, Apr 30. PMID:32438322 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-2 microglobulin 3D structures MHC 3D structures MHC I 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA