5h7e

Crystal Structure of native drCPDase

spinqualitylabelsall models 5h7e, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5h7e is a 1 chain structure with sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.6Å Ligands: GOL, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O32509_DEIRD Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.[HAMAP-Rule:MF_01940] Publication Abstract from PubMed 2',3'-Cyclic phosphodiesterase (CPDase) homologues have been found in all domains of life and are involved in diverse RNA and nucleotide metabolisms. The CPDase from Deinococcus radiodurans was crystallized and the crystals diffracted to 1.6 A resolution, which is the highest resolution currently known for a CPDase structure. Structural comparisons revealed that the enzyme is in an open conformation in the absence of substrate. Nevertheless, the active site is well formed, and the representative motifs interact with sulfate ion, which suggests a conserved catalytic mechanism. Crystal structure of the RNA 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.,Han W, Cheng J, Zhou C, Hua Y, Zhao Y Acta Crystallogr F Struct Biol Commun. 2017 May 1;73(Pt 5):276-280. doi:, 10.1107/S2053230X17004964. Epub 2017 Apr 26. PMID:28471359 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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